Formulation and evaluation of spirulina, red algae, and jack fruit seed powders infused anti-aging cream: In Silico analysis and physiochemical characteristics

• Novel combination of anti-aging cream with Spirulina, Red algae, and Jack fruit seed. • In silico analysis. • VOC Potentiality against Collagenase using Molecular Dynamic Simulation. The present work aims to formulate a non-toxic, 100 % natural anti-aging cream with the combination of red algae, green algae, and Jack fruit seed for the first time. The Gas chromatography and Mass spectrometry (GC–MS) analysis of green algae, red algae, and jackfruit seed showed the presence of six different potential anti-aging compounds. We carried out docking studies of the compounds identified from Gas chromatography and Mass spectrometry (GC–MS) using the Schrodinger suite with collagenase enzyme. The findings indicated that all the compounds interact potentially with collagenase with binding energy 1-Iodo-2-methylundecane (-4 Kcal/mol), Estra-1,3,5(10)-trien-17-beta.-ol (-6.9 Kcal/mol), Tetradecane (-7 Kcal/mol), 8-Hydroxyguanosine (-7.7 Kcal/mol), niacin (Niacin)amide (-4.3 Kcal/mol) and Linoelaidic acid (-7 Kcal/mol) and also verified using Molecular Dynamic Simulation. Then, the microalgae and jackfruit seed-infused anti-aging cream were prepared using the FSSAI-approved protocol reported in the literature and confirmed with proper consistency, odour, and colour in four trials. Among the four trials, trial 4 exhibited good colour and pleasant smell. The cream (trial 4) also showed anti-microbial activity for better stability. That proves the cream efficiently treats microorganisms, which play a prominent role in collagen degradation in the face skin. The shelf life of the cream is extended up to 6 months, where the cream is stored in optimum conditions.