Key result
Stearic acid stimulates phosphatidylcholine biosynthesis in isolated hearts via enhanced microsomal cytidylyltransferase activity.
Population
Isolated hamster hearts
Comparison
Perfusion with labelled choline in the presence of stearic, oleic, or arachidonic acids
Design
Ex vivo animal perfusion study
Authors
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No immediate clinical implications from hamster heart data; leaves open translation of fatty acid effects on cytidylyltransferase to human cardiac metabolism.
Stearic acid selectively stimulates phosphatidylcholine biosynthesis in the hamster heart via activation of microsomal CTP:phosphocholine cytidylyltransferase.
Mock et al. (1986) studied this question. Fatty acids (stearic, oleic, and arachidonic acids) was evaluated on Phosphatidylcholine biosynthesis. Perfusion of isolated hamster hearts with stearic acid, but not oleic or arachidonic acids, stimulated phosphatidylcholine biosynthesis via enhancement of microsomal cytidylyltransferase activity.
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