Key result
Intravenous miconazole linked to fatal bradyarrhythmia and VF upon rechallenge in a heart transplant recipient.
Why the study?
Does intravenous miconazole cause fatal dysrhythmia in patients with underlying heart disease?
Population
A 54-year-old male heart transplant recipient with subcutaneous Scopulariopsis infection
Design
Case report
Authors
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Raises caution for IV miconazole in heart disease; single case leaves causal risk open for confirmation.
Case Report (n=1)
Does intravenous miconazole cause fatal dysrhythmia in patients with underlying heart disease?
Intravenous miconazole can induce fatal cardiac arrhythmias, particularly in patients with underlying heart disease, warranting extreme caution.
Coley et al. (1997) conducted a case report in Scopulariopsis infection (n=1). Intravenous miconazole was evaluated on Bradyarrhythmia progressing to ventricular fibrillation and death. Intravenous miconazole administration in a 54-year-old heart transplant recipient resulted in a fatal bradyarrhythmia that progressed to ventricular fibrillation upon rechallenge.
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