Key result
mRNA-1273 COVID-19 vaccine linked to 4 cases of acute myocarditis-like illness.
Why the study?
Messenger RNA COVID-19 vaccines typically cause minor and transient side effects, prompting the report of acute myocarditis-like illness following vaccination.
Does mRNA COVID-19 vaccination cause acute myocarditis-like illness?
Case Report (n=4)
No
Does mRNA COVID-19 vaccination cause acute myocarditis-like illness?
This case series highlights a potential rare safety signal of acute myocarditis-like illness following mRNA COVID-19 vaccination.
May signal rare myocarditis after mRNA-1273; hypothesis-generating and leaves causality and incidence open pending larger studies.
Messenger RNA vaccines are the main COVID-19 vaccines authorized for use in the United States. Side effects are typically minor and transient. We report a case series of four subjects with an acute myocarditis-like illness following mRNA COVID-19 vaccination who were hospitalized at our hospital in Lubbock, Texas. Three patients were young men who presented with acute chest pain after the second dose of the mRNA-1273 vaccine. Another patient was a 53-year-old white woman who presented with acute left arm pain 3 days after the first dose of the mRNA-1273 vaccine. She was later found to have acute decompensated heart failure, and endomyocardial biopsy revealed eosinophilic injury-mediated myocarditis.
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Parmar et al. (2021) conducted a case report in Acute myocarditis-like illness (n=4). mRNA-1273 COVID-19 vaccine was evaluated. Four patients developed acute myocarditis-like illness, including one with biopsy-proven eosinophilic injury-mediated myocarditis, following administration of the mRNA-1273 COVID-19 vaccine.
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