December 1, 1979Clinical Science
Plasma Catecholamines and Blood Pressure Responses to the Carotid Baroreceptor Reflex in Essential Hypertension
Key result
Altering carotid transmural pressure changes arterial pressure without affecting plasma catecholamines, revealing their poor sensitivity.
Why the study?
The sensitivity of plasma catecholamine measurements to detect moderate changes in sympathetic tone induced by carotid baroreceptor reflex alterations in essential hypertension was unclear.
Do moderate changes in sympathetic tone induced by carotid baroreceptor reflex alter systemic plasma catecholamine levels in subjects with essential hypertension?
Population
Subjects with essential hypertension
Comparison
Reflex increases and decreases in sympathetic activity induced by carotid transmural pressure changes and tilting
Design
Physiological study using variable pressure neck-chamber technique and tilting
Authors
Discussion
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Implication
Plasma catecholamines may not sensitively index moderate sympathetic changes in hypertension; leaves open their utility for detecting marked activation.
Structured PICO
Do moderate changes in sympathetic tone induced by carotid baroreceptor reflex alter systemic plasma catecholamine levels in subjects with essential hypertension?
P
Population
Subjects with essential hypertension undergoing experimental manipulation of carotid baroreceptor activity.
I
Intervention
Alterations in carotid transmural pressure using variable pressure neck-chamber technique, and tilting
O
Outcome
Changes in arterial pressure and plasma catecholamines (noradrenaline and adrenaline)surrogate
Measurements of systemic plasma catecholamines may not be a sensitive index for moderate changes in sympathetic tone, though they reflect marked sympathetic activation.
Cite This Study
Mancia et al. (1979) studied Essential hypertension. Alterations in carotid transmural pressure (variable pressure neck-chamber technique) was evaluated on Plasma catecholamines and arterial pressure. Alterations in carotid transmural pressure changed arterial pressure without significantly altering plasma catecholamines, suggesting they are not a sensitive index of moderate sympathetic changes.