Key result
A small molecule prevented ventricular arrhythmia in a mutant mouse model by strengthening a critical calcium channel against the effects of chronic adrenergic stimulation.
A small molecule targeting calcium channels may prevent ventricular arrhythmias in the setting of heart failure, based on preclinical evidence.
A recent study in a mutant mouse model shows that a small molecule can strengthen a critical calcium channel against the effects of chronic adrenergic stimulation and thus prevent ventricular arrhythmia.
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Farr et al. (2004) studied this question. A small molecule prevented ventricular arrhythmia in a mutant mouse model by strengthening a critical calcium channel against the effects of chronic adrenergic stimulation.
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