Key result
Chronic alveolar hypoxia elevates lung and serum ACE activity in mice alongside increased renal renin.
Authors
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Hypothesis-generating in murine hypoxia; leaves open ACE's role in human pulmonary vascular disease.
Molteni et al. (1974) studied this question. Chronic alveolar hypoxia was evaluated on Lung and serum angiotensin I converting enzyme activity. Chronic alveolar hypoxia in mice led to elevations of serum and lung angiotensin I converting enzyme activity during the second week of exposure, which correlated with increased renal renin granules.
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