Key result
Acute alveolar hypoxia reduces Angiotensin I conversion by ~50% in dogs, independent of hemodynamics.
Why the study?
The regulation of angiotensin I conversion during acute alveolar hypoxia and its underlying mechanisms were not well understood.
Population
Dogs under acute alveolar hypoxia
Comparison
Conversion of AI at PaO2 30 mm Hg vs control values
Design
In vivo physiological study
Authors
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Hypoxia may impair pulmonary angiotensin conversion; leaves open relevance to human RAS modulation in hypoxemia.
Leuenberger et al. (1978) studied Acute alveolar hypoxia. Acute alveolar hypoxia vs. Control values was evaluated on Conversion of Angiotensin I to Angiotensin II. Acute alveolar hypoxia (PaO2 of 30 mm Hg) decreased the in vivo conversion of Angiotensin I to one half of control values in dogs, independent of hemodynamic factors.
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