Why the study?
Does angiotensin infusion enhance hypoxic pulmonary vasoconstriction in isolated dog lungs?
Population
Blood-perfused isolated dog lungs using a double-perfusion system
Comparison
Infusion of either angiotensin I or angiotensin II vs Control lung from the same animal
Design
Preclinical
Authors
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May augment HPV in isolated canine lungs; leaves open translation to human pulmonary vascular disease.
Does angiotensin infusion enhance hypoxic pulmonary vasoconstriction in isolated dog lungs?
Angiotensin I and II temporarily enhance hypoxic pulmonary vasoconstriction in isolated dog lungs.
Alexander et al. (1976) studied this question.
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