Effect of acute hypoxia on the pulmonary conversion of angiotensin I to angiotensin II in dogs.
Key result
Acute hypoxia significantly decreased the pulmonary conversion of tracer doses of angiotensin I to II from 72% to 67% (P<0.005) in anesthetized dogs.
Why the study?
Does acute hypoxia reduce the pulmonary conversion of angiotensin I to angiotensin II in anesthetized dogs?
Population
Anesthetized dogs
Comparison
Acute hypoxia vs Normoxia (arterial PO2 86 +/- 14 mm Hg)
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Acute hypoxia impairs pulmonary angiotensin conversion in dogs; leaves open effects on human ACE activity during hypoxemia.
Structured PICO
Does acute hypoxia reduce the pulmonary conversion of angiotensin I to angiotensin II in anesthetized dogs?
P
Population
Anesthetized dogs subjected to acute hypoxia to evaluate pulmonary conversion of angiotensin I to II.
I
Intervention
Acute hypoxia (arterial PO2 decreased to 33 +/- 8 mm Hg)
C
Comparator
Normoxia (arterial PO2 86 +/- 14 mm Hg)
O
Outcome
Pulmonary conversion of intravenous boluses of radiolabeled angiotensin I to angiotensin IIsurrogate
Main Result
Absolute Event Rate: 67% vs 72%
p-value: p=<0.005
Acute hypoxia reversibly decreases pulmonary angiotensin converting enzyme availability in a canine model.
Cite This Study
Szidon et al. (1980) studied this question. Acute hypoxia vs. Normoxia was evaluated on Pulmonary conversion of tracer doses of angiotensin I to II (p=<0.005). Acute hypoxia significantly decreased the pulmonary conversion of tracer doses of angiotensin I to II from 72% to 67% (P<0.005) in anesthetized dogs.