Key result
Review outlines the epidemiology, pathophysiology, and optimal management of concurrent HF and CKD.
This review highlights the challenges and optimal management strategies for patients with co-existing chronic heart failure and chronic kidney disease, a population often excluded from major clinical trials.
Highlights challenges in managing concomitant HF and CKD; leaves open optimal strategies due to frequent trial exclusions.
Chronic kidney disease and chronic heart failure are closely interlinked; an abnormality in one system adversely impacts upon the function of the other. Despite the wealth of evidence available for beneficial treatment strategies in chronic heart failure, the prognosis remains poor and optimum therapy under-utilised. The applicability of proven therapies to patients with co-morbidity remains a particular challenge, especially since marked renal impairment has often been an exclusion criteria in major studies. In this article we discuss the epidemiology and pathophysiology of the two conditions and then focus on the aspects of treatment most pertinent to those patients with heart failure patients and concomitant chronic kidney disease.
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Zachariah et al. (2009) conducted a review in Chronic heart failure and chronic kidney disease. This review discusses the epidemiology, pathophysiology, and optimal management strategies for patients with concomitant chronic heart failure and chronic kidney disease.
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