What does this research mean for the field?

Neomycin fixation combined with ethanol pretreatment preserves glycosaminoglycans and inhibits in vivo calcification in bioprosthetic heart valve tissue compared to glutaraldehyde fixation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 6, 2009Journal of Biomedical Materials Research Part B Applied BiomaterialsOpen Access

Neomycin fixation followed by ethanol pretreatment leads to reduced buckling and inhibition of calcification in bioprosthetic valves

Q: What is the clinical evidence from this study?

Study design: Other. Population: Bioprosthetic heart valve calcification and degeneration. Intervention: Neomycin fixation followed by ethanol pretreatment vs. Glutaraldehyde (GLUT) control. Primary outcome: Calcification and glycosaminoglycan (GAG) stabilization.

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Key result

Neomycin fixation plus ethanol pretreatment inhibits calcification and preserves glycosaminoglycans versus glutaraldehyde in rat implants.

Why the study?

Does neomycin fixation followed by ethanol pretreatment prevent calcification and preserve glycosaminoglycans in bioprosthetic heart valves compared to glutaraldehyde fixation?

Population

Bioprosthetic heart valve cusps (in vitro) and rat subdermal implantation model (in vivo)

Comparison

Neomycin fixation followed by ethanol… vs Glutaraldehyde (GLUT) fixation control

Design

Preclinical

Authors

DRDevanathan Raghavan SSSagar ShahJohnson & Johnson (United States)NVNaren VyavahareClemson University

Discussion

Member takes

Implication

Should not yet change bioprosthetic valve fixation; hypothesis-generating for reduced calcification in clinical implants.

Structured PICO

Does neomycin fixation followed by ethanol pretreatment prevent calcification and preserve glycosaminoglycans in bioprosthetic heart valves compared to glutaraldehyde fixation?

Population

In vitro and in vivo (subdermal implantation in rats) evaluation of neomycin fixed bioprosthetic heart valves pretreated with ethanol.

Intervention

Neomycin fixation followed by ethanol pretreatment or sodium borohydride treatment

Comparator

Glutaraldehyde (GLUT) fixation control

Outcome

Calcification and glycosaminoglycan (GAG) preservationsurrogate

Neomycin fixation followed by ethanol pretreatment of bioprosthetic heart valves preserves glycosaminoglycans and inhibits calcification in a rat model, potentially increasing valve durability.

Cite This Study

Raghavan et al. (2009) studied Bioprosthetic heart valve calcification and degeneration. Neomycin fixation followed by ethanol pretreatment vs. Glutaraldehyde (GLUT) control was evaluated on Calcification and glycosaminoglycan (GAG) stabilization. Neomycin fixation followed by ethanol pretreatment effectively preserved glycosaminoglycans and inhibited in vivo calcification in rat subdermal implants compared to glutaraldehyde control.

synapsesocial.com/papers/6aa8a3f4c419fc5b3cb5c849 https://doi.org/10.1002/jbm.b.31503

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Neomycin fixation followed by ethanol pretreatment leads to reduced buckling and inhibition of calcification in bioprosthetic valves

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Neomycin fixation followed by ethanol pretreatment leads to reduced buckling and inhibition of calcification in bioprosthetic valves

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider