Key result
Prasugrel 100 mg loading dose trends toward lower 2-hour platelet reactivity versus 60 mg.
Why the study?
Does a high (100 mg) loading dose of prasugrel improve platelet inhibition compared to a standard (60 mg) loading dose in patients with STEMI undergoing primary PCI?
Does a high (100 mg) loading dose of prasugrel improve platelet inhibition compared to a standard (60 mg) loading dose in patients with STEMI undergoing primary PCI?
Mean Difference: -45.5 (95% CI -91.2–0.3)
p-value: p=0.051
A 100 mg loading dose of prasugrel provides greater and more consistent early platelet inhibition compared to the standard 60 mg dose in STEMI patients undergoing primary PCI.
Higher prasugrel loading may enhance early inhibition in STEMI; hypothesis-generating and should not yet change practice.
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Alexopoulos et al. (2014) studied ST-segment-elevation myocardial infarction (n=82). Prasugrel vs. 60 mg loading dose was evaluated on Platelet reactivity (in P2Y12 reaction units) at hour 2 (MD -45.5, 95% CI -91.2 to 0.3, p=0.051). A 100 mg loading dose of prasugrel compared with 60 mg showed a strong trend toward lower platelet reactivity at 2 hours (mean difference -45.5; 95% CI -91.2 to 0.3; P=0.051).
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