Key result
Arterial baroreflex sensitivity peaks prenatally and drops postnatally while early cardiopulmonary regulation remains impaired.
This review highlights that arterial baroreflex sensitivity is highest during fetal life and decreases postnatally, with distinct hormonal regulatory mechanisms compared to adults.
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Developmental baroreflex patterns may inform neonatal autonomic assessment; extends comparative physiology but leaves open human interventional studies.
Jeffrey L. Segar (1997) conducted a review in Developmental changes in cardiovascular autonomic reflexes. Developmental changes (fetal and postnatal life) vs. Adult life was evaluated. Arterial baroreflex sensitivity is greatest during fetal life and decreases postnatally, whereas cardiopulmonary mechanoreceptor regulation is impaired early in development compared to adults.
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