Key result
CRT linked to ~11% lower RPP-normalized MVO2 at 3-4 months, suggesting improved efficiency.
Why the study?
Experimental studies indicated unfavourable effects on myocardial energetics and efficiency under asynchronous ventricular stimulation and left bundle branch block pattern.
Does cardiac resynchronization therapy improve myocardial oxygen consumption and perfusion in patients with dilated cardiomyopathy and LBBB?
Population
31 patients with dilated cardiomyopathy and LBBB
Comparison
After CRT vs before CRT (baseline)
Design
Observational study
Follow-up
3–4 months
Authors
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CRT may improve energetics in DCM with LBBB; leaves open clinical outcome impact in larger trials.
Observational (n=31)
Does cardiac resynchronization therapy improve myocardial oxygen consumption and perfusion in patients with dilated cardiomyopathy and LBBB?
Absolute Event Rate: 0.072% vs 0.081%
p-value: p=<0.05
Cardiac resynchronization therapy improves myocardial pressure work efficiency and reverses regional myocardial oxygen dysbalance without increasing absolute global myocardial oxygen consumption in the short term.
D. Baller (2004) conducted an observational in Dilated cardiomyopathy (DCM) and left bundle branch block (LBBB) (n=31). Cardiac resynchronization therapy (CRT) vs. Baseline (before CRT) was evaluated on Rate pressure product (RPP)-normalized myocardial oxygen consumption (MVO2) (p=<0.05). Cardiac resynchronization therapy significantly decreased RPP-normalized myocardial oxygen consumption from 0.081/min at baseline to 0.072/min at 3-4 months (P<0.05), suggesting improved efficiency.
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