What is the clinical evidence from this study?

Study design: Case Report. Population: Pulmonary embolism with biatrial thrombi (n=1). Intervention: Unfractionated heparin infusion. Primary outcome: Hemodynamic stabilization and regression of atrial masses.

What does this research mean for the field?

In oncological patients with unexplained clinical deterioration, intracardiac masses may be thrombotic rather than malignant, and multimodality imaging is crucial for accurate diagnosis and management. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To describe the diagnosis and successful management of severe pulmonary embolism with a biatrial thrombus mimicking cardiac malignancy in a patient with high bleeding risk.

September 15, 2026European Heart Journal Supplements

Pulmonary Embolism With Biatrial Thrombi Mimicking Cardiac Involvement in an Oncological Patient

View Full Paper

Ask AI

Bookmark

Key result

Unfractionated heparin infusion rapidly resolves biatrial thrombi and stabilizes hemodynamics in a patient with PE.

Population

A 76-year-old man with stage IV-B diffuse large B-cell gastric lymphoma

Design

Case report

Authors

DFD FabbriOspedale Martini MMM MartinelliOspedale Martini RSR SartorOspedale Martini

Discussion

Member takes

Implication

Supports heparin trial in suspected biatrial thrombi mimicking malignancy in lymphoma; leaves open prospective validation.

Key Points

To describe the diagnosis and successful management of severe pulmonary embolism with a biatrial thrombus mimicking cardiac malignancy in a patient with high bleeding risk.
Clinical evaluation of a 76-year-old male receiving chemotherapy for stage IV-B gastric lymphoma who presented with persistent hypotension, hypoxemic respiratory alkalosis, and right heart strain.
Multimodality imaging including transthoracic echocardiography, computed tomography angiography, and positron emission tomography to evaluate intracardiac masses and pulmonary vasculature.
Initiation of intravenous unfractionated heparin after multidisciplinary risk-benefit balancing of severe thromboembolism against high gastrointestinal bleeding risk.
Computed tomography angiography confirmed bilateral pulmonary embolism and a large intracardiac thrombus straddling a patent foramen ovale into both atria, coinciding with severe right ventricular dysfunction.
Unfractionated heparin therapy led to rapid hemodynamic stabilization, progressive normalization of right ventricular function, and complete regression of the biatrial masses without bleeding complications.
Follow-up positron emission tomography successfully excluded malignant cardiac lymphoma involvement.

Study Design

Type

Case Report (n=1)

Structured PICO

Population

A 76-year-old man with stage IV-B diffuse large B-cell gastric lymphoma who developed pulmonary embolism and biatrial thrombi.

Intervention

Unfractionated heparin infusion followed by oral anticoagulation

Outcome

Hemodynamic stabilization, recovery of right ventricular function, reduction of pulmonary pressures, and regression of atrial masses

In oncological patients with unexplained clinical deterioration, pulmonary embolism and thrombotic intracardiac masses should be considered and can be successfully managed with anticoagulation despite high bleeding risk.

Cite This Study

Fabbri et al. (2026) conducted a case report in Pulmonary embolism with biatrial thrombi (n=1). Unfractionated heparin infusion was evaluated on Hemodynamic stabilization and regression of atrial masses. Unfractionated heparin infusion led to rapid hemodynamic stabilization and regression of atrial masses in a 76-year-old man with pulmonary embolism and biatrial thrombi.

synapsesocial.com/papers/6aa9017deed42882c1fc192e https://doi.org/10.1093/eurheartjsupp/suag058.386

Topics

Heart failure HFrEF treatment Pulmonary embolism

View Full Paper

Ask AI

Bookmark

Pulmonary Embolism With Biatrial Thrombi Mimicking Cardiac Involvement in an Oncological Patient

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Topics

Pulmonary Embolism With Biatrial Thrombi Mimicking Cardiac Involvement in an Oncological Patient

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider