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December 3, 1955JAMA

Intramuscular Use of Dimenhydrinate (Dramamine) to Control Postoperative Vomiting

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Why the study?

Does intramuscular dimenhydrinate reduce postoperative vomiting?

Population

Patients at risk for postoperative vomiting

Design

Other

Authors

DMDaniel C. MooreDeakin University

Discussion

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Implication

Dimenhydrinate may halve postoperative vomiting; leaves open efficacy pending rigorous randomized confirmation.

Structured PICO

Does intramuscular dimenhydrinate reduce postoperative vomiting?

P
Population
Patients at risk for postoperative vomiting
I
Intervention
Intramuscular dimenhydrinate
O
Outcome
Postoperative vomiting (amount past 50 cc)

This text discusses methodological objections to a prior report on the efficacy of intramuscular dimenhydrinate for postoperative vomiting.

Limitations

  • Lack of placebo control in preliminary report
  • Insufficient sample size in preliminary report
  • Incomplete quantification of vomiting past 50 cc

Cite This Study

Daniel C. Moore (1955) studied this question.

synapsesocial.com/papers/6aa90949b17909331cd9251bhttps://doi.org/10.1001/jama.1955.02960310006005
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effectiveness of dimenhydrinate and maropitant in preventing preoperative emesis and nausea in healthy dogs sedated with hydromorphone and dexmedetomidine: a randomized, blinded trial2026
  2. 2BEYOND ANTIEMESIS: EVALUATING INTRAVENOUS DIMENHYDRINATE AS AN ADJUNCT TO CONSCIOUS SEDATION IN IVF OOCYTE RETRIEVALS THROUGH A PROSPECTIVE COHORT STUDY2026
  3. 3Granisetron for Postoperative Nausea and Vomiting Prophylaxis in Microvascular Decompression Despite Prominent Non-serotonergic Emetic Pathways2026
  4. 4A COMPARATIVE STUDY OF ONDANSETRON VERSUS METOCLOPRAMIDE IN THE PREVENTION OF POST-OPERATIVE VOMITING IN ROUTINE MAJOR GYNECOLOGICAL SURGERY UNDER GENERAL ANESTHESIA1970 · 1 citations
  5. 5Ondansetron in the Treatment of Postoperative Vomiting1992 · 150 citations