Key result
Eclampsia is linked to ~13-fold higher serum troponin I levels versus normotensive pregnancies.
Observational (n=166)
Yes
Absolute Event Rate: 0.18% vs 0.0134%
p-value: p=0.016
Serum troponin I is elevated in eclampsia but not preeclampsia, suggesting myocardial damage in eclampsia, whereas D-Dimer is elevated in both conditions.
May warrant cardiac evaluation in eclampsia; observational data leaves open whether troponin elevation reflects injury or alters management.
OBJECTIVE: The aim of this study was to evaluate serum cardiac troponin I and D-Dimer (D-Di) levels in preeclampsia (PE), eclampsia (E), and normotensive healthy pregnant women in third trimester in order to define their diagnostic value. MATERIALS AND METHODS: The study group consisted of 42 preeclamptic patients and 16 eclamptic patient; 108 healthy normotensive pregnant women in third trimester who were chosen from outpatients clinic and examined regularly used as a control group. Serum cardiac troponin I and D-Di levels were measured using an immunoassay. RESULTS: The average levels of troponin I were 0.0134 ± 0.0091, 0.017 ± 0.0085, 0.180 ± 0.136 in control group, preeclamptic, and eclamptic patients, respectively. The levels of troponin in eclamptic patients were statistically higher than the normotensive and preeclamptic group (p = 0.016, p = 0.014). There were no differences in terms of troponin I level between preeclamptic group and normotensive pregnant women in third trimester (p = 0.089). The average D-Di levels were 634 ± 228 ng/ml, 1426 ± 430 ng/ml, 2067 ± 580 ng/ml in control group, preeclamptic, and eclamptic patients, respectively. The levels of D-Di in preeclamptic and eclamptic patients were found significantly higher than the control groups (p = 0.034, p = 0.020). CONCLUSION: Serum troponin I levels increased in eclamptic patient because of myocardial damage. An increased level of troponin was not detected in preeclamptic patients. However; D-Di level increased in preeclamptic and eclamptic patients.
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Bozkurt et al. (2015) conducted an observational in Preeclampsia and Eclampsia (n=166). Eclampsia and Preeclampsia vs. Healthy normotensive pregnant women was evaluated on Serum cardiac troponin I levels (ng/ml) (p=0.016). Eclampsia was associated with significantly higher serum troponin I levels (0.180 ng/ml) compared to normotensive pregnancies (0.0134 ng/ml, p=0.016), while D-Dimer levels were elevated in both preeclampsia and eclampsia.
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