Key result
Fibroblast growth factors stimulate while mesangial cells inhibit glomerular endothelial cell proliferation in vitro.
Why the study?
To enable the study of glomerular endothelial cell functions and interactions with other glomerular cells by establishing bovine glomerular capillary endothelial cells in culture and investigating their growth regulation.
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Population
Bovine glomerular capillary endothelial cells in culture
Design
In vitro cell culture study
Authors
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Does not yet alter clinical management of glomerular disease; leaves open the role of these mechanisms in vivo.
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Bovine glomerular endothelial cell growth is under autocrine and paracrine control, stimulated by fibroblast growth factors and inhibited by mesangial cells.
Barbara J. Ballermann (1989) studied Bovine glomerular endothelial cell growth. Fibroblast growth factors and cell coculture was evaluated on Endothelial cell proliferation. Proliferation of bovine glomerular endothelial cells in vitro was stimulated by fibroblast growth factors and inhibited by mesangial cell coculture, suggesting autocrine and paracrine control.
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