Key result
Abnormal ventricular-vascular coupling is linked to an AIx up to ~19% versus optimal coupling.
Why the study?
Little is known regarding the physiologic correlates of augmentation index derived from peripheral arterial tonometry (PAT-AIx).
Is elevated augmentation index derived from peripheral arterial tonometry associated with abnormal ventricular-vascular coupling?
Observational (n=47)
Is elevated augmentation index derived from peripheral arterial tonometry associated with abnormal ventricular-vascular coupling?
p-value: p=<0.05
Abnormal ventricular-vascular coupling, whether from increased arterial or ventricular elastance, is associated with an increased augmentation index measured by peripheral arterial tonometry.
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May link peripheral AI to ventricular-vascular mismatch; hypothesis-generating and requires prospective validation before clinical use.
Heffernan et al. (2010) reported an observational. Abnormal ventricular-vascular coupling vs. Optimal ventricular-vascular coupling was evaluated on Augmentation index (AIx) derived from peripheral arterial tonometry (p=<0.05). Abnormal ventricular-vascular coupling is associated with increased augmentation index compared to optimal coupling (13% for low and 19% for high vs 1% for optimal coupling; P<0.05).