Key result
Metoprolol maintains acute systolic BP reduction despite subsequent alcohol consumption in healthy men.
Why the study?
Does a single oral dose of 200 mg of metoprolol compared to placebo maintain its antihypertensive effect on supine systolic blood pressure after consuming alcohol in healthy men?
Population
8 healthy men
Comparison
Single oral dose of 200 mg of metoprolol… vs Placebo followed by alcohol
Design
RCT, randomized
Follow-up
acute
Authors
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Metoprolol's acute BP-lowering effect persists after alcohol; supports use without restriction in this context and extends interaction data to pharmacodynamics.
RCT (n=8)
randomized
Does a single oral dose of 200 mg of metoprolol compared to placebo maintain its antihypertensive effect on supine systolic blood pressure after consuming alcohol in healthy men?
Acute alcohol consumption does not abolish the blood pressure-lowering effect of a single dose of metoprolol in healthy men.
Maheswaran et al. (2008) conducted an RCT in Healthy (n=8). Metoprolol followed by alcohol vs. Placebo followed by alcohol was evaluated on Supine systolic blood pressure. A single 200 mg oral dose of metoprolol maintained its acute antihypertensive effect on supine systolic blood pressure despite subsequent consumption of 0.75 g/kg of alcohol in healthy men.
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