Key result
Women undergoing TAVI show a ~29% lower rate of post-procedural AR ≥ 2 than men.
Why the study?
Does female sex impact the incidence of post-procedural aortic regurgitation and mid-term mortality in patients undergoing TAVI?
Population
656 patients with aortic stenosis (53.1% women, 46.9% men)
Comparison
Transcatheter aortic valve implantation using… vs Comparison between female and male patients
Design
Cohort
Follow-up
median 434 days
Authors
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Suggests sex may modify TAVI complications; hypothesis-generating and should not yet change practice or device selection.
Cohort (n=656)
Does female sex impact the incidence of post-procedural aortic regurgitation and mid-term mortality in patients undergoing TAVI?
Absolute Event Rate: 20.7% vs 26.6%
p-value: p=0.10
Women undergoing TAVI have a lower incidence of post-procedural AR ≥ 2 compared to men, which contributes to a trend toward lower mid-term mortality, although female sex itself is not an independent predictor of death.
Ferrante et al. (2014) conducted a cohort in Aortic stenosis (n=656). Female sex vs. Male sex was evaluated on All-cause mortality (p=0.10). Women undergoing TAVI had a lower incidence of post-procedural aortic regurgitation ≥ 2 than men (20.9% vs 29.6%, P=0.01) and a trend toward lower all-cause mortality (20.7% vs 26.6%, P=0.10).
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