Key result
Isolated systolic hypertension linked to reduced arterial compliance, increased LV stress, and ~80% exercise ST-segment depression.
Why the study?
Alterations in cardiac function and coronary circulation in patients with isolated systolic hypertension were not well characterized.
Does isolated systolic hypertension alter left ventricular wall stress and coronary circulation compared to normotensive subjects?
Comparison
Patients with isolated systolic hypertension versus normotensive control subjects
Design
Case-control study with cardiac catheterization and intracoronary Doppler measurements
Authors
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May indicate ischemia risk in isolated systolic hypertension; leaves open causal role of compliance in prospective studies.
Case-Control (n=17)
Does isolated systolic hypertension alter left ventricular wall stress and coronary circulation compared to normotensive subjects?
Absolute Event Rate: 80% vs 0%
p-value: p=< 0.01
Patients with isolated systolic hypertension exhibit decreased arterial compliance, increased left ventricular systolic wall stress, and reduced coronary flow reserve, which may contribute to subendocardial ischemia during exercise.
Ohtsuka et al. (1996) conducted a case-control in Isolated systolic hypertension (n=17). Isolated systolic hypertension vs. Normotensive subjects was evaluated on ST-segment depression on the exercise electrocardiogram (p=< 0.01). Isolated systolic hypertension was associated with decreased arterial compliance, increased left ventricular wall stress, and frequent ST-segment depression during exercise (80% vs 0%, P<0.01).
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