Key result
Patients with isolated systolic hypertension had significantly lower coronary flow reserve compared to those with combined systolic/diastolic hypertension (2.22 vs 2.49, P=0.03), indicating more profound impairment of coronary microvascular function.
Why the study?
Does isolated systolic hypertension compared to combined systolic/diastolic hypertension reduce coronary flow reserve in elderly patients without CAD or diabetes?
Cross-Sectional (n=76)
Single-blind
No
Does isolated systolic hypertension compared to combined systolic/diastolic hypertension reduce coronary flow reserve in elderly patients without CAD or diabetes?
Absolute Event Rate: 2.22% vs 2.49%
p-value: p=0.03
Isolated systolic hypertension is associated with more profoundly impaired coronary microvascular function compared to combined systolic/diastolic hypertension in elderly patients.
Authors
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Supports association of isolated systolic hypertension with worse microvascular function; leaves open prognostic or therapeutic implications in elderly patients.
Bozbaş et al. (2012) conducted a cross-sectional in Hypertension (n=76). Isolated systolic hypertension vs. Combined systolic/diastolic hypertension was evaluated on Coronary flow reserve (CFR) (p=0.03). Patients with isolated systolic hypertension had significantly lower coronary flow reserve compared to those with combined systolic/diastolic hypertension (2.22 vs 2.49, P=0.03), indicating more profound impairment of coronary microvascular function.
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