Key result
Chemoreceptor inactivation in dogs reveals pressoreceptors alone can drive sustained arterial pressure waves.
Why the study?
The contribution of pressoreceptors versus chemoreceptors to arterial blood pressure waves was unclear.
This preclinical study demonstrates that pressoreceptors alone can supply sufficient feedback to cause arterial pressure waves in the absence of functioning chemoreceptors.
Authors
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Reinforces baroreceptor independence in canine models; leaves open translation to human baroreflex physiology.
Armstrong et al. (1962) studied this question. Chemoreceptor inactivation by intra-arterial injection of acetic acid was evaluated on Arterial blood pressure waves (damped and spontaneous sustained Mayer type). Chemoreceptor inactivation in dogs demonstrated that pressoreceptors alone are capable of supplying sufficient feedback to cause damped and sustained arterial pressure waves.
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