Why the study?
Common and unique mechanisms between asthma and postinfectious bronchiolitis obliterans in children with wheezing are not clear.
What are the unique and common proteomic biomarkers between children with asthma and postinfectious bronchiolitis obliterans?
Population
30 healthy children, 18 with asthma, and 15 with PIBO
Comparison
Children with asthma vs PIBO vs healthy controls
Design
Proteomic analysis study
Key result
Proteomic analysis identified 48 significantly different proteins, revealing TGF-β1 and periostin as unique biomarkers for PIBO and asthma, respectively, which negatively correlated with lung function.
Authors
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Hypothesis-generating for TGF-β1 and periostin as distinct biomarkers in pediatric PIBO versus asthma; requires prospective validation before clinical use.
Observational (n=63)
What are the unique and common proteomic biomarkers between children with asthma and postinfectious bronchiolitis obliterans?
TGF-β1 and periostin serve as unique plasma biomarkers for postinfectious bronchiolitis obliterans and asthma in children, respectively, with potential therapeutic relevance for the IKBKB pathway.
Kang et al. (2022) conducted an observational in Asthma and postinfectious bronchiolitis obliterans (PIBO) (n=63). Asthma and PIBO vs. Healthy controls was evaluated on Differentially expressed proteins in plasma. Proteomic analysis identified 48 significantly different proteins, revealing TGF-β1 and periostin as unique biomarkers for PIBO and asthma, respectively, which negatively correlated with lung function.