Key result
Higher plasma sFlt-1 is linked to CAD and multivessel disease in hypertensive patients.
Why the study?
The association between vascular endothelial growth factor, soluble fms-like tyrosine kinase 1, and coronary artery disease severity was investigated.
Are plasma levels of VEGF and sFlt-1 associated with the presence and severity of coronary artery disease in hypertensive patients?
Case-Control (n=224)
Are plasma levels of VEGF and sFlt-1 associated with the presence and severity of coronary artery disease in hypertensive patients?
p-value: p=0.01
Plasma sFlt-1 levels are positively associated with the presence and angiographical severity of CAD in hypertensive patients.
May support VEGF as CAD biomarker in hypertension; hypothesis-generating and requires prospective validation before clinical use.
BACKGROUND: The association between vascular endothelial growth factor (VEGF), soluble fms-like tyrosine kinase 1 (sFlt-1), and coronary artery disease (CAD) was investigated. METHODS: We enrolled 112 hypertensive patients with proven CAD and 112 hypertensive controls matched for age and gender. The severity of CAD was assessed by the most severe clinical presentation of CAD in patients' history and by the number of diseased vessels. RESULTS: Vascular endothelial growth factor level was lower, whereas sFlt-1 level was higher in the CAD group compared to the controls. Diabetes mellitus (P = .001), smoking (P = .004), and higher sFlt-1 level (P = .01) were independently associated with CAD. Younger age (P = .02), smoking (P = .049), and higher VEGF levels (P = .02) were independently associated with a history of myocardial infarction (MI), whereas higher sFlt-1 level (P = .01) was independently associated with multivessel disease. CONCLUSION: Plasma sFlt-1 levels are positively associated with the presence of CAD and are associated with angiographical severity of CAD.
No takes yet. Share an insight, caveat, or question.
Kim et al. (2010) conducted a case-control in Coronary artery disease (n=224). Vascular endothelial growth factor (VEGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) levels vs. Hypertensive controls without CAD was evaluated on Presence of CAD (p=0.01). Higher plasma sFlt-1 levels were independently associated with the presence of coronary artery disease (P=0.01) and multivessel disease (P=0.01) in hypertensive patients.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: