December 1, 1976Clinical Science
Altered Angiotensin I Conversion in Pulmonary Disease
Key result
Sarcoidosis is linked to a ~2-fold higher angiotensin I requirement for complete ACE inhibition.
- n=41
Why the study?
Plasma converting enzyme activity may reflect pulmonary conversion and can be altered by pulmonary disease, but its measurement and implications require characterization.
How is plasma angiotensin I converting enzyme activity altered in patients with pulmonary diseases compared to normal subjects?
Comparison
Plasma converting enzyme activity in pulmonary disease patients vs normal subjects
Design
Observational cross-sectional study
Authors
Discussion
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Implication
ACE activity may be elevated in sarcoidosis and reduced in COPD; hypothesis-generating for its utility in renin-angiotensin studies.
Study Design
Type
Observational (n=41)
Structured PICO
How is plasma angiotensin I converting enzyme activity altered in patients with pulmonary diseases compared to normal subjects?
P
Population
41 subjects including 15 normal subjects, 11 with sarcoidosis, 12 with chronic obstructive pulmonary disease, and 3 with shock lung.
C
Comparator
Normal subjects
O
Outcome
Plasma angiotensin I converting enzyme activitysurrogate
Plasma converting enzyme activity is altered by pulmonary disease, being increased in sarcoidosis and decreased in COPD and shock lung, suggesting its potential utility in studying the renin-angiotensin system.
Cite This Study
Oparil et al. (1976) conducted an observational in Pulmonary disease (sarcoidosis, chronic obstructive pulmonary disease, shock lung) (n=41). Pulmonary disease vs. Normal subjects was evaluated on Plasma angiotensin I converting enzyme activity. Patients with sarcoidosis required twice as much exogenous angiotensin I to completely inhibit plasma converting enzyme activity, while COPD patients required one tenth as much as normal subjects.