Key result
A radioimmunoassay method determined the half-lives for angiotensin-I in normal rat and human plasma to be 0.8-2.1 min, and for angiotensin-II in normal human plasma to be 10 min.
Population
Normal rat and human plasma, and plasma from salt-depleted, renal hypertensive, and nephrectomized rats
Design
Preclinical
Authors
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Short plasma angiotensin half-lives may refine kinetic models; leaves open in vivo translation to human cardiovascular regulation.
A radioimmunoassay method was developed to simultaneously determine plasma converting enzyme and angiotensinase activity, demonstrating short half-lives for angiotensin-I and II in rat and human plasma.
Poulsen et al. (1971) studied Plasma converting enzyme and angiotensinase activity. Radioimmunoassay was evaluated on Half-lives for angiotensin-I and angiotensin-II. A radioimmunoassay method determined the half-lives for angiotensin-I in normal rat and human plasma to be 0.8-2.1 min, and for angiotensin-II in normal human plasma to be 10 min.
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