Key result
CRT reduces IL-6 by ~47% and lowers sICAM-1, persisting three months after pacing discontinuation.
Why the study?
Cardiac resynchronization therapy has been proposed to improve heart failure patients with left ventricular asynchrony, but its influence on proinflammatory cytokines was unclear.
Does cardiac resynchronization therapy reduce proinflammatory cytokines in patients with severe chronic heart failure?
Comparison
CRT pacing for 3 months vs baseline and subsequent 3-month no pacing period
Design
Cohort study
Follow-up
6 months
Authors
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Supports anti-inflammatory effects of CRT in severe HF; hypothesis-generating and should not yet change practice.
Does cardiac resynchronization therapy reduce proinflammatory cytokines in patients with severe chronic heart failure?
p-value: p=<0.05
Cardiac resynchronization therapy reduces proinflammatory cytokines and adhesion molecules in patients with severe chronic heart failure, with effects persisting even after temporary discontinuation of pacing.
Theodorakis et al. (2006) studied chronic heart failure (n=20). Cardiac resynchronization therapy (CRT) pacing vs. Baseline (pre-pacing) and no-pacing period was evaluated on Levels of proinflammatory cytokines (TNF-alpha, IL-6) and adhesion molecules (p=<0.05). Cardiac resynchronization therapy reduced IL-6 (from 8.9 to 4.7 pg/mL, P<0.05) and sICAM-1 levels, with effects maintained for at least 3 months after pacing discontinuation.
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