Key result
Changes in systolic dyssynchrony, sphericity, and coaptation distance are linked to dynamic MR during exercise.
Why the study?
Left ventricular shape and dyssynchrony are cofactors associated with functional mitral regurgitation in heart failure, but their relationship with dynamic MR during exercise is unclear.
Are exercise-induced changes in LV shape and dyssynchrony assessed by 3D echocardiography associated with dynamic functional mitral regurgitation in patients with systolic LV dysfunction?
Observational (n=50)
Are exercise-induced changes in LV shape and dyssynchrony assessed by 3D echocardiography associated with dynamic functional mitral regurgitation in patients with systolic LV dysfunction?
Effect estimate: r2 = 0.45
p-value: p=0.012
Dynamic functional mitral regurgitation during exercise is related to 3D echocardiographic changes in LV shape and synchronicity in patients with systolic LV dysfunction.
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Dynamic MR associates with exercise-induced LV shape and dyssynchrony changes on 3DE; leaves open whether these parameters aid risk stratification in systolic HF.
Izumo et al. (2009) conducted an observational in Systolic LV dysfunction (n=50). Dynamic mitral regurgitation during exercise vs. No dynamic mitral regurgitation during exercise was evaluated on Association with dynamic changes in systolic dyssynchrony index, sphericity index, and coaptation distance (r2 = 0.45, p=0.012). Dynamic changes in the systolic dyssynchrony index, sphericity index, and coaptation distance were significantly associated with dynamic mitral regurgitation during exercise (r2 = 0.45, P = 0.012).
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