What does this research mean for the field?

Anticardiolipin antibodies are frequently present in HIV-infected individuals regardless of disease progression stage and are independently associated with viral replication, immune activation, and antibodies targeting the membrane-proximal external region of gp41. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 26, 2008Clinical Infectious Diseases

Anticardiolipin Antibodies in HIV Infection Are Independently Associated with Antibodies to the Membrane Proximal External Region of gp41 and with Cell‐Associated HIV DNA and Immune Activation

Q: What is the clinical evidence from this study?

Study design: Observational. Population: HIV infection (n=117). Intervention: Slow progression of HIV disease vs. Standard disease progression. Primary outcome: Detection of anticardiolipin (aCL) immunoglobulin G.

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Key result

Anticardiolipin antibodies strongly correlate with viral load and appear in ~49% of HIV slow progressors.

n=117

Why the study?

The relationship between anticardiolipin antibodies and HIV-specific broadly neutralizing antibodies, immune activation, and viral indicators in HIV infection was unclear.

Comparison

Slow progression of HIV disease vs standard disease progression

Design

Observational study

Authors

VMValérie MartinezUniversidad Santiago de Cali MDMarie‐Claude DiemertDélégation Paris 6 MBMartine BraibantUniversité de Tours

Discussion

Member takes

Implication

Anticardiolipin antibodies associate with HIV viremia; hypothesis-generating for thrombotic cardiovascular risk and requires prospective validation.

Study Design

Type

Observational (n=117)

Structured PICO

Population

117 HIV-infected individuals, comprising 67 untreated asymptomatic slow progressors and 50 standard progressors, evaluated for autoantibodies.

Comparator

Standard disease progression (control patients)

Outcome

Correlation of anticardiolipin (aCL) antibodies with HIV-specific broadly neutralizing antibodies, immune activation, and virological/clinical indicatorssurrogate

Main Result

Absolute Event Rate: 49% vs 58%

Anticardiolipin antibodies are frequently detected in HIV-infected patients and are strongly linked with viral replication and immune activation, independent of CD4+ cell deficiency.

Cite This Study

Martinez et al. (2008) conducted an observational in HIV infection (n=117). Slow progression of HIV disease vs. Standard disease progression was evaluated on Detection of anticardiolipin (aCL) immunoglobulin G. Anticardiolipin antibodies were detected in 49% of HIV slow progressors and 58% of standard progressors, and strongly correlated with viral load (P<0.001).

synapsesocial.com/papers/6aaa4ac7f5e945fe6954c36c https://doi.org/10.1086/595013

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Implication

Anticardiolipin antibodies associate with HIV viremia; hypothesis-generating for thrombotic cardiovascular risk and requires prospective validation.

Anticardiolipin Antibodies in HIV Infection Are Independently Associated with Antibodies to the Membrane Proximal External Region of gp41 and with Cell‐Associated HIV DNA and Immune Activation

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Cite This Study

Anticardiolipin Antibodies in HIV Infection Are Independently Associated with Antibodies to the Membrane Proximal External Region of gp41 and with Cell‐Associated HIV DNA and Immune Activation

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider