Key result
Persistent RV impairment early after TMVr is linked to ~125% higher death and HF hospitalization risk.
Why the study?
The change in right-ventricular function after transcatheter mitral valve repair is still poorly understood.
Does the early response of right-ventricular function to transcatheter mitral valve repair predict mortality and heart failure hospitalization in patients with mitral regurgitation?
Population
816 consecutive patients undergoing MitraClip for mitral regurgitation
Comparison
Right-ventricular function before and after MitraClip procedure
Design
Cohort study from Heart Failure Network Rhineland registry
Follow-up
2 years
Authors
Loading...
May aid post-TMVR prognostication via early RV assessment; extends observational data but leaves causal impact open.
Cohort (n=816)
Yes
Does the early response of right-ventricular function to transcatheter mitral valve repair predict mortality and heart failure hospitalization in patients with mitral regurgitation?
Hazard Ratio: 2.25 (95% CI 1.47–3.44)
Absolute Event Rate: 46% vs 20%
p-value: p=<0.001
Early changes in right ventricular function after transcatheter mitral valve repair are strongly predictive of 2-year mortality and heart failure hospitalization.
Sugiura et al. (2021) conducted a cohort in Mitral regurgitation (n=816). Persistently impaired right-ventricular function vs. Stable/normal right-ventricular function was evaluated on Composite of all-cause mortality and hospitalization due to heart failure within 2 years (HR 2.25, 95% CI 1.47-3.44, p=<0.001). Persistently impaired right-ventricular function early after transcatheter mitral valve repair was associated with an increased risk of mortality and heart failure hospitalization (HR 2.25).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: