Rest and exercise haemodynamics in patients with one of two stented bioprostheses and in healthy controls with small aortic annuli†
Key result
Trifecta bioprosthesis is linked to ~4 mmHg lower resting mean gradients versus Perimount Magna Ease.
- n=76
Why the study?
Does the Trifecta bioprosthesis improve rest and exercise haemodynamics compared to the Perimount Magna Ease bioprosthesis in patients with small aortic annuli?
Population
35 patients with Trifecta, 16 with PME bioprostheses, and 25 healthy controls with small aortic annuli
Comparison
Trifecta bioprosthesis vs Perimount Magna Ease bioprosthesis vs healthy controls
Design
Observational study using transthoracic echocardiography during rest and exercise
Follow-up
1 year for Trifecta, 2.6 years for PME
Authors
Discussion
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Implication
Does not support changing valve selection; leaves open whether hemodynamic gains improve clinical outcomes in randomized data.
Study Design
Type
Observational (n=76)
Structured PICO
Does the Trifecta bioprosthesis improve rest and exercise haemodynamics compared to the Perimount Magna Ease bioprosthesis in patients with small aortic annuli?
P
Population
76 participants, including 35 with Trifecta valves, 16 with Perimount Magna Ease valves (size ≤ 23 mm), and 25 healthy controls, evaluated at rest and during exercise.
E
Exposure
Trifecta bioprosthesis (size ≤ 23 mm)
C
Comparator
Perimount Magna Ease (PME) bioprosthesis (size ≤ 23 mm) and healthy controls
O
Outcome
Mean transvalvular gradient, effective orifice area (EOA), and EOA index during rest and exercise using transthoracic echocardiographysurrogate
Main Result
Absolute Event Rate: 7.96% vs 12.19%
The Trifecta bioprosthesis demonstrates superior haemodynamic performance at rest and during exercise compared to the Perimount Magna Ease in patients with small aortic annuli.
Cite This Study
Stock et al. (2017) conducted an observational in Bioprosthetic aortic valve replacement with small aortic annuli (n=76). Trifecta bioprosthesis vs. Perimount Magna Ease (PME) bioprosthesis was evaluated on Mean transvalvular gradient at rest (mmHg). The Trifecta bioprosthesis demonstrated significant haemodynamic superiority over the Perimount Magna Ease, with lower mean transvalvular gradients at rest (7.96 vs 12.19 mmHg) and during exercise.