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February 11, 2022ESC Heart FailureOpen Access

The Value of Echocardiographic Measurement of Epicardial Adipose Tissue in Heart Failure Patients

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Key result

Echocardiographic EAT thickness shows modest correlation with CMR volume and limited interobserver agreement.

  • R2 = 0.38
  • P<0.001
  • n=117

Why the study?

Epicardial adipose tissue (EAT) is important in heart failure pathophysiology, but echocardiographic measurement of EAT thickness and its relation to CMR-measured EAT volume is unclear.

Does echocardiographic measurement of epicardial adipose tissue thickness accurately estimate EAT volume compared to cardiac magnetic resonance imaging in patients with heart failure?

Population

117 heart failure patients with LVEF >40%, mean age 71 ± 10 years, 49% women

Comparison

Echocardiographic EAT thickness vs CMR EAT volume

Design

Cross-sectional study

Authors

GWGijs van WoerdenDVDirk J. van VeldhuisenTGThomas M. Gorter

Discussion

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Overview

Echocardiographic EAT thickness shows limited accuracy and modest agreement with CMR in HF; leaves open need for standardized protocols and prospective validation.

Study Design

Type

Cross-Sectional (n=117)

Structured PICO

Does echocardiographic measurement of epicardial adipose tissue thickness accurately estimate EAT volume compared to cardiac magnetic resonance imaging in patients with heart failure?

P
Population
117 patients with heart failure and left ventricular ejection fraction >40% (mean age 71 years, 49% women) undergoing both CMR and echocardiography.
E
Exposure
Echocardiographic measurement of epicardial adipose tissue (EAT) thickness
C
Comparator
Cardiac magnetic resonance (CMR) imaging measurement of EAT volume
O
Outcome
Correlation between EAT volume on CMR and EAT thickness on echocardiography, and interobserver/intraobserver agreementsurrogate

Main Result

Effect estimate: R2 = 0.38

p-value: p=<0.001

Echocardiographic measurement of epicardial adipose tissue thickness has limited accuracy and modest interobserver agreement for estimating EAT volume compared to CMR in heart failure patients.

Limitations

  • Limited agreement between junior and senior observers for measuring echocardiographic EAT

Cite This Study

Woerden et al. (2022) conducted a cross-sectional in Heart failure (n=117). Echocardiographic EAT thickness vs. CMR EAT volume was evaluated on Correlation between EAT volume on CMR and EAT thickness on echocardiography (R2 = 0.38, p=<0.001). Echocardiographic epicardial adipose tissue thickness showed modest correlation with CMR volume (R2=0.38, P<0.001) and had limited interobserver agreement (ICC 0.65).

synapsesocial.com/papers/6aab5531d69ea1ca52f690a2https://doi.org/10.1002/ehf2.13828
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Volumetric Assessment of Epicardial Adipose Tissue With Cardiovascular Magnetic Resonance Imaging2007 · 212 citations
  2. 2Importance of epicardial adipose tissue localization using cardiac magnetic resonance imaging in patients with heart failure with mid‐range and preserved ejection fraction2021 · 50 citations
  3. 3Epicardial Fat from Echocardiography: A New Method for Visceral Adipose Tissue Prediction2003 · 782 citations
  4. 4Pericardial Rather Than Epicardial Fat is a Cardiometabolic Risk Marker: An MRI vs Echo Study2011 · 128 citations
  5. 5Evaluation of right ventricular volume and function by 2D and 3D echocardiography compared to MRI2005 · 287 citations