Key result
Elevated homocysteine is present in 72% of young adults with acute myocardial infarction.
Why the study?
The prevalence of acute myocardial infarction is increasing in young adults, and the relationship of serum lipoprotein, homocysteine, and hs-CRP levels with AMI risk requires clinical correlation.
Observational (n=50)
No
Elevated levels of homocysteine, hs-CRP, and lipoprotein A, along with low HDL-C, are correlated with acute myocardial infarction in young adults.
Answers are grounded in this paper and cite their sources.
Elevated homocysteine may correlate with young AMI; hypothesis-generating and should not change practice without prospective validation.
• Introduction - Recently, the prevalence of acute myocardial infarction (AMI) has been increasing in the younger generation. With the advances in the field of medicine, elevated serum levels of various biomarkers like c-reactive protein (CRP), various lipoproteins and homocysteine have been identified to be related to AMI. • Objective - To clinically diagnose acute myocardial infarction in young patients and correlate the levels of serum lipoprotein, serum homocysteine and serum hs-crp and to calculate the level of risk depending on their levels. • Method - A hospital based observational study in which 50 subjects were enrolled in the study as per the inclusion and exclusion criteria. • Results - The results support the current global findings of the younger generation, especially the males, being affected by AMI (Acute Myocardial Infarction). Sedentary lifestyle and BMI >25 can be considered as major risk factors leading to AMI. A considerable proportion of our AMI patients had significantly elevated levels of homocysteine, hs-CRP and lipoprotein A and low levels of HDL-C indicating their correlation with AMI.
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Felin Ann Francis (2020) conducted an observational in Acute Myocardial Infarction (n=50). Elevated serum homocysteine vs. Normal serum homocysteine levels was evaluated on Proportion of patients with significant serum homocysteine levels (≥30 µmol/L) (p=0.0013). Among young adults with acute myocardial infarction, a significant proportion (72%) presented with elevated serum homocysteine levels (≥30 µmol/L).
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