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September 17, 2026Journal of drug targeting

A Repurposed Olmesartan-Loaded Hyaluronic Acid-Functionalized Lecithin–Chitosan Nanoparticle Hydrogel for Enhanced Topical Delivery in Diabetic Wound Healing

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Authors

WEWalaa A. El‐DakrouryGAGihan F. AsaadASAl-Aliaa M. Sallam

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Overview

Preclinical study reveals topical olmesartan nanoparticle hydrogel accelerates wound closure in diabetic rats, suggesting an effective repurposed nanomedicine for chronic wound management.

Key Points

  • To formulate and evaluate a repurposed olmesartan medoxomil-loaded, hyaluronic acid-functionalized lecithin–chitosan nanoparticle hydrogel for sustained topical delivery and enhanced diabetic wound repair.
  • Fabricated hyaluronic acid-functionalized lecithin–chitosan nanoparticles encapsulating olmesartan medoxomil (OLM-HA-LCNPs) and dispersed them into a hydrogel base.
  • Characterized particle size, zeta potential, entrapment efficiency, rheological behavior, and in vitro biphasic release kinetics over 24 hours.
  • Assessed in vivo wound closure, antioxidant markers, and histological remodeling over 14 days in streptozotocin-induced diabetic rats across comparative treatment arms.
  • OLM-HA-LCNP hydrogel achieved 93.5% wound closure at day 14 compared with 87.6% for marketed reference, 77.1% for plain HA–LCNPs, and 90.8% for pure OLM.
  • Treatment increased catalase, superoxide dismutase, and glutathione by 2.7-, 1.45-, and 2.16-fold, respectively, and reduced malondialdehyde levels by 77% relative to diabetic controls.
  • Histological and immunohistochemical analyses demonstrated accelerated re-epithelialization, enhanced collagen deposition, and normalized expression of VEGF and MMP-9.

Cite This Study

El‐Dakroury et al. (2026) studied this question.

synapsesocial.com/papers/6aabb6635f706d05830e4c37https://doi.org/10.1080/1061186x.2026.2733606
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Also Consider

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  1. 1In vitro and in vivo evaluation of oleuropein loaded hyalurosomes for diabetic foot ulcer healing2026
  2. 2Potential Therapeutic Benefits of Lutein-loaded Hydrogel in Diabetic-Induced Dermal Wound Healing.2026
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  4. 4A Tissue‐Homologous Keratin‐PBA Hydrogel Integrating Rationally Designed Nanomicelles Enables Microenvironment‐Adaptive Repair of Chronic Diabetic Wounds2026
  5. 5Liposome integrated hydrogel for diabetic wound healing: Molecular mechanisms in inflammation and oxidative stress mitigation2025