Key result
Higher BMI is the primary predictor of third-trimester arterial stiffness in preeclampsia, independent of inflammation.
Why the study?
Preeclampsia involves systemic inflammation, endothelial dysfunction, and vascular abnormalities, but the relationships among IL-6, proteinuria, and arterial stiffness remain unclear.
Cross-Sectional (n=87)
No
Effect estimate: β = 0.634 (95% CI 0.469-0.799)
p-value: p=<0.001
In women with preeclampsia, arterial stiffness increases progressively during pregnancy and is independently predicted by BMI, whereas systemic inflammation (IL-6) correlates with renal involvement (proteinuria) rather than mechanical arterial stiffness.
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BMI may guide preeclampsia vascular risk assessment; leaves open distinct IL-6 pathways for proteinuria versus stiffness.
Petre et al. (2026) conducted a cross-sectional in Preeclampsia (n=87). Body mass index (BMI) and Interleukin-6 (IL-6) was evaluated on Third-trimester aortic pulse wave velocity (PWVao) (β = 0.634, 95% CI 0.469-0.799, p=<0.001). Among women with preeclampsia, body mass index was the main independent predictor of third-trimester arterial stiffness (β = 0.634), whereas systemic inflammation (IL-6) was associated with proteinuria but not arterial stiffness.
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