What is the clinical evidence from this study?

Study design: Cohort. Population: Subclinical coronary calcification (n=803). Intervention: Polygenic Risk Scores (PRS) vs. Lower PRS. Primary outcome: Percentile CACS (CACS ≥75th age-/sex-adjusted percentile) (median OR 1.41).

What does this research mean for the field?

Most publicly available coronary artery disease polygenic risk scores significantly predict clinically actionable coronary artery calcification independently of traditional risk factors, especially in individuals at low clinical risk. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the effectiveness of 53 publicly available coronary artery disease polygenic risk scores in predicting clinically significant, subclinical coronary calcification.

September 17, 2026European Journal of Preventive CardiologyOpen Access

Higher CAD polygenic risk scores linked to ~41% greater odds of elevated CACS per SD.

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Why the study?

Few studies have examined the effectiveness of CAD MACE polygenic risk scores in detecting individuals with subclinical coronary calcification.

Do publicly available CAD polygenic risk scores predict clinically significant coronary calcification in patients referred for CCTA?

Population

803 BioHEART-CT Discovery 1000 participants referred for CT coronary angiography

Comparison

53 publicly available CAD polygenic risk score tools

Design

Cohort study

Key result

Polygenic risk scores for coronary artery disease were significantly associated with coronary calcification, with a median OR of 1.41 per SD increase for CACS ≥75th percentile.

Authors

MGMichael P. Gray DSDario Strbenac DMDaniel G. MacArthur

Discussion

Member takes

Overview

May aid stratification in CCTA referrals; extends PRS-MACE data to subclinical calcification but leaves adoption open pending validation.

Key Points

To evaluate the effectiveness of 53 publicly available coronary artery disease polygenic risk scores in predicting clinically significant, subclinical coronary calcification.
Analyzed 53 publicly available coronary artery disease polygenic risk scores (PRS) in 803 participants from the BioHEART-CT Discovery cohort referred for CT coronary angiography.
Evaluated associations with two binary outcomes: absolute coronary artery calcium score (CACS ≥100 Agatston units) and percentile CACS (≥75th age- and sex-adjusted percentile).
Adjusted multivariable models for genetic principal components, modifiable cardiovascular risk factors, and age/sex, with subgroup analysis stratified by baseline Framingham Risk Score.
Among 803 participants, 487 (60.6%) had detectable coronary calcium, and 94.3% of continuous PRS tools significantly associated with percentile CACS ≥75th after full adjustment (median OR 1.41 per SD, IQR 1.23–1.60).
Participants in the highest PRS quintile had up to a 7.99-fold increased odds of percentile CACS ≥75th compared to the lowest quintile.
In participants classified as low risk by Framingham Risk Score, adding PRS elevated the pre-test probability of significant coronary calcification from 14% to 26%.

Study Design

Type

Cohort (n=803)

Structured PICO

Do publicly available CAD polygenic risk scores predict clinically significant coronary calcification in patients referred for CCTA?

Population

803 participants presenting for clinically referred CT coronary angiography evaluated for associations between CAD polygenic risk scores and coronary calcification.

Exposure

53 publicly available CAD Polygenic Risk Scores (PRS) tools

Outcome

Absolute CACS (CACS ≥100 Agatston units [AU]) and Percentile CACS (CACS ≥75th age-/sex-adjusted percentile)surrogate

Main Result

Odds Ratio: 1.41

Publicly available CAD polygenic risk scores can predict clinically relevant coronary calcification, particularly in individuals traditionally considered lower risk by Framingham Risk Score.

Cite This Study

Gray et al. (2026) conducted a cohort in Subclinical coronary calcification (n=803). Polygenic Risk Scores (PRS) vs. Lower PRS was evaluated on Percentile CACS (CACS ≥75th age-/sex-adjusted percentile) (median OR 1.41). Polygenic risk scores for coronary artery disease were significantly associated with coronary calcification, with a median OR of 1.41 per SD increase for CACS ≥75th percentile.

synapsesocial.com/papers/6aabb8375f706d05830e7cb7 https://doi.org/10.1093/eurjpc/zwag480

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September 17, 2026European Journal of Preventive CardiologyOpen Access

Higher CAD polygenic risk scores linked to ~41% greater odds of elevated CACS per SD.

View Full Paper

Ask AI

Bookmark

Why the study?

Few studies have examined the effectiveness of CAD MACE polygenic risk scores in detecting individuals with subclinical coronary calcification.

Do publicly available CAD polygenic risk scores predict clinically significant coronary calcification in patients referred for CCTA?

Population

803 BioHEART-CT Discovery 1000 participants referred for CT coronary angiography

Comparison

53 publicly available CAD polygenic risk score tools

Design

Cohort study

Key result

Polygenic risk scores for coronary artery disease were significantly associated with coronary calcification, with a median OR of 1.41 per SD increase for CACS ≥75th percentile.

Authors

MGMichael P. Gray DSDario Strbenac DMDaniel G. MacArthur

Discussion

Member takes

Overview

May aid stratification in CCTA referrals; extends PRS-MACE data to subclinical calcification but leaves adoption open pending validation.

Key Points

To evaluate the effectiveness of 53 publicly available coronary artery disease polygenic risk scores in predicting clinically significant, subclinical coronary calcification.
Analyzed 53 publicly available coronary artery disease polygenic risk scores (PRS) in 803 participants from the BioHEART-CT Discovery cohort referred for CT coronary angiography.
Evaluated associations with two binary outcomes: absolute coronary artery calcium score (CACS ≥100 Agatston units) and percentile CACS (≥75th age- and sex-adjusted percentile).
Adjusted multivariable models for genetic principal components, modifiable cardiovascular risk factors, and age/sex, with subgroup analysis stratified by baseline Framingham Risk Score.
Among 803 participants, 487 (60.6%) had detectable coronary calcium, and 94.3% of continuous PRS tools significantly associated with percentile CACS ≥75th after full adjustment (median OR 1.41 per SD, IQR 1.23–1.60).
Participants in the highest PRS quintile had up to a 7.99-fold increased odds of percentile CACS ≥75th compared to the lowest quintile.
In participants classified as low risk by Framingham Risk Score, adding PRS elevated the pre-test probability of significant coronary calcification from 14% to 26%.

Study Design

Type

Cohort (n=803)

Structured PICO

Do publicly available CAD polygenic risk scores predict clinically significant coronary calcification in patients referred for CCTA?

Population

803 participants presenting for clinically referred CT coronary angiography evaluated for associations between CAD polygenic risk scores and coronary calcification.

Exposure

53 publicly available CAD Polygenic Risk Scores (PRS) tools

Outcome

Absolute CACS (CACS ≥100 Agatston units [AU]) and Percentile CACS (CACS ≥75th age-/sex-adjusted percentile)surrogate

Main Result

Odds Ratio: 1.41

Publicly available CAD polygenic risk scores can predict clinically relevant coronary calcification, particularly in individuals traditionally considered lower risk by Framingham Risk Score.

Cite This Study

synapsesocial.com/papers/6aabb8375f706d05830e7cb7 https://doi.org/10.1093/eurjpc/zwag480

View Full Paper

Ask AI

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