Key result
Enflurane increases AV and accessory pathway refractoriness more than isoflurane or halothane in WPW syndrome.
Why the study?
The effects of volatile anesthetics and sufentanil on the electrophysiologic properties of the accessory pathway and intraoperative tachyarrhythmias in Wolff-Parkinson-White syndrome were unknown.
Do volatile anesthetics and sufentanil alter the electrophysiologic properties of the accessory pathway and atrioventricular node in patients with Wolff-Parkinson-White syndrome?
Comparison
1 MAC halothane vs isoflurane vs enflurane after sufentanil-lorazepam anesthesia
Design
Randomized controlled trial
Follow-up
Intraoperative
Authors
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Volatile agents prolong accessory pathway refractoriness in WPW; leaves open optimal choice for ablation versus nonablative procedures.
RCT (n=21)
randomized
Do volatile anesthetics and sufentanil alter the electrophysiologic properties of the accessory pathway and atrioventricular node in patients with Wolff-Parkinson-White syndrome?
Volatile anesthetics, especially enflurane, increase refractoriness in accessory and atrioventricular pathways in WPW syndrome, potentially confounding post-ablation testing but offering protection against perioperative tachyarrhythmias.
Sharpe et al. (1994) conducted an RCT in Wolff-Parkinson-White syndrome (n=21). Halothane, isoflurane, or enflurane vs. Baseline (sufentanil-lorazepam anesthesia) was evaluated on Electrophysiologic properties of the accessory pathway and atrioventricular node. In patients with Wolff-Parkinson-White syndrome, enflurane most, isoflurane next, and halothane least increased refractoriness within the accessory and atrioventricular pathways.
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