Why the study?
The recent withdrawal of a targeted sepsis therapy has reduced pharmaceutical enthusiasm for developing novel sepsis drugs, motivating investigation of angiopoietin-2 regulation as a therapeutic target.
Does simvastatin reduce angiopoietin-2 production and improve survival in sepsis models?
RCT
Placebo-controlled
Randomized
Yes
Does simvastatin reduce angiopoietin-2 production and improve survival in sepsis models?
Statins may ameliorate sepsis manifestations by suppressing angiopoietin-2 production via a Foxo1-dependent mechanism.
Hypothesis-generating for simvastatin in sepsis; leaves open survival benefit and human translation.
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Ghosh et al. (2015) conducted an RCT in Sepsis. Simvastatin vs. Placebo was evaluated on Circulating Angiopoietin-2 levels.
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