Key result
Intravenous methoxamine increases peak systolic and time-averaged velocity and raises systolic blood pressure versus placebo.
Why the study?
Non-invasive methods to assess vascular effects of antimigraine drugs require evaluation for utility, variability, and sensitivity using a vasoconstrictor probe drug.
Do non-invasive techniques accurately assess vasoconstriction induced by intravenous methoxamine in healthy volunteers?
RCT (n=6)
Double-blind
Do non-invasive techniques accurately assess vasoconstriction induced by intravenous methoxamine in healthy volunteers?
Ultrasound and oscillometric or strain gauge methods are reliable non-invasive techniques for assessing methoxamine-induced vasoconstriction, whereas Finapres is less reflective of blood pressure changes.
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Ultrasound enables reliable non-invasive vascular monitoring for antimigraine drugs; extends methodological tools for future clinical trials.
Dixon et al. (1996) conducted an RCT in Healthy volunteers (n=6). Methoxamine vs. Placebo was evaluated on Vascular effects including changes in arterial diameter, velocity, and blood pressure. Intravenous methoxamine increased peak systolic and time-averaged velocity, while oscillometric and strain gauge methods successfully detected drug-related increases in systolic blood pressure.
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