Key result
Adrenal diffuse large B-cell lymphoma shows up to ~90% PD-L1 expression, suggesting potential for checkpoint inhibitors.
Why the study?
Primary adrenal lymphoma is a rare malignancy with poor prognosis and no consensus classification or specialized treatment, requiring further clinical understanding.
Case Report (n=2)
High PD-L1 expression in primary adrenal lymphoma suggests a potential role for early use of immunological checkpoint inhibitors, especially in rituximab-resistant cases.
Hypothesis-generating for checkpoint inhibitors in adrenal DLBCL; larger prospective studies required before clinical consideration.
BACKGROUND: Primary adrenal lymphoma (PAL) is an infrequent malignant disease and there is no consensus classification or specialized treatment for it. However, PAL has been observed to have worse prognosis compared with other extrarenal malignant lymphomas and diffuse large B-cell lymphoma presents as the most common subtype of PAL. METHODS: The current study reported two cases of adrenal diffuse large B-cell lymphoma with high PD-L1 expression and discussed the clinical significance of PD-L1 through literature review. KEY RESULTS: The PD-L1 expression rate of the two cases was 90% and 80%, respectively, which was significantly higher than those reported in the literature. CONCLUSION: PAL is a type of non-Hodgkin's lymphoma with low incidence and poor prognosis, and it is necessary to further explore the early use of immunological checkpoint inhibitors for patients with higher expression of PD-L1 and with rituximab-resistance.
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Chen et al. (2020) conducted a case report in Adrenal diffuse large B-cell lymphoma (n=2). PD-L1 expression was evaluated on PD-L1 expression rate. Two cases of adrenal diffuse large B-cell lymphoma showed high PD-L1 expression rates of 90% and 80%, suggesting a potential role for immunological checkpoint inhibitors.
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