Key result
Children with Down syndrome and heart disease face ~33% mortality, driven by complete AVC and TOF.
Why the study?
The clinical course and outcomes of cardiac disease in infants and children with Down's syndrome were not well characterized.
Population
369 infants and children with Down's syndrome including 230 with heart disease
Design
Observational cohort study
Authors
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High mortality signals need for expert multidisciplinary care; leaves open targeted strategies for AV canal and TOF lesions.
Observational (n=369)
Infants and children with Down's syndrome and heart disease have a high prevalence of endocardial cushion defects and face a high medical and surgical mortality rate of 33%.
Greenwood et al. (1976) conducted an observational in Down's syndrome and heart disease (n=369). Heart disease in Down's syndrome was evaluated on Medical and surgical mortality. Among infants and children with Down's syndrome and heart disease, medical and surgical mortality was 33%, especially in those with complete atrioventricular canals and tetralogy of Fallot.
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