Key result
Serum or gelatin pretreatment minimizes enterovirus loss during membrane filtration.
Why the study?
Extensive or total losses of enterovirus during membrane filtration due to adsorption to the membrane matrix were observed, and methods to minimize this were investigated.
Population
Two species of enteroviruses
Comparison
Filtration with serum incorporation or membrane pretreatment vs filtration without these measures
Design
Experimental study of virus filtration through membranes of varying porosity
Authors
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May enhance virus recovery in research filtration; leaves open clinical translation pending validation.
Adding serum or gelatin during membrane filtration of enteroviruses minimizes virus loss due to membrane adsorption.
Dean O. Cliver (1965) studied Enterovirus filtration. Membrane filtration with serum or gelatin pretreatment vs. Filtration without pretreatment was evaluated on Virus loss during filtration. Extensive enterovirus loss during membrane filtration due to adsorption can be minimized by incorporating serum into the suspension or pretreating the membrane with serum or gelatin.
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