Key result
Mathematical modeling evaluates optimal vaccination and culling strategies for cost-effective foot-and-mouth disease control.
Why the study?
Foot-and-mouth disease threatens economic security and animal health, and optimal strategies for vaccination and culling to control outbreaks need to be evaluated.
Mathematical modeling provides a framework for evaluating the cost-effectiveness of vaccination and culling strategies to control Foot-and-Mouth Disease outbreaks.
Modeling aids FMD control planning; leaves open real-world validation before guiding policy.
Foot-and-mouth disease (FMD) is a threat to economic security and infrastructure as well as animal health, in both developed and developing countries. We propose and analyze an optimal control problem where the control system is a mathematical model for FMD that incorporates vaccination and culling of infectious animals. The control functions represent the fraction of animals that are vaccinated during an outbreak, infectious symptomatic animals that are detected and culled, and infectious nonsymptomatic animals that are detected and culled. Our aim was to study how these control measures should be implemented for a certain time period, in order to reduce or eliminate FMD in the community, while minimizing the interventions implementation costs. A cost-effectiveness analysis is carried out, to compare the application of each one of the control measures, separately or in combination.
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Mushayabasa et al. (2015) studied Foot-and-mouth disease (FMD). Vaccination and culling of infectious animals was evaluated on Reduction or elimination of FMD and minimization of intervention implementation costs. A mathematical model and cost-effectiveness analysis were proposed to evaluate the optimal implementation of vaccination and culling strategies for controlling foot-and-mouth disease.
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