Key result
Heterologous A22 Iraq vaccination boosts antibody titers versus no vaccination in calves with maternal antibodies.
Why the study?
Maternal antibodies can interfere with foot-and-mouth disease vaccination, and strategies to improve herd immunity in their presence are needed.
Does intratypic heterologous vaccination improve antibody response in calves with maternal antibodies against foot-and-mouth disease virus?
Does intratypic heterologous vaccination improve antibody response in calves with maternal antibodies against foot-and-mouth disease virus?
Intratypic heterologous vaccination may improve immunity in calves with maternal antibodies against foot-and-mouth disease virus during emergency vaccination.
Answers are grounded in this paper and cite their sources.
Supports further study of intratypic heterologous FMD vaccination in calves with maternal antibodies; leaves open any role in emergency control.
BACKGROUND: Maternal antibodies can interfere with foot-and-mouth disease vaccination. In this study we determined whether intratypic heterologous vaccination could help to improve herd immunity. RESULTS: In unvaccinated calves, a half-life of maternal antibodies of 21 days was determined. At two weeks of age, calves without maternal antibodies showed a good antibody response against both vaccines used in the trial, while in calves with maternal antibodies no antibody response to homologous vaccination (A Turkey 14/98) but a limited antibody response to intratypic heterologous vaccination (A22 Iraq) was observed. CONCLUSION: Two weeks old calves without maternal antibodies respond well to vaccination, but when emergency vaccination is carried out in a region that uses prophylactic vaccination, using an intratypic heterologous vaccine strain may improve the immunity in calves with maternal antibodies.
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Dekker et al. (2014) studied Foot-and-mouth disease virus (FMDV) (n=25). Intratypic heterologous vaccination (A 22 Iraq) vs. Homologous vaccination (A Turkey 14/98) or no vaccination was evaluated on Neutralising antibody titre against FMDV (p=0.002). In calves with maternal antibodies against A Turkey 14/98, intratypic heterologous vaccination with A 22 Iraq induced significantly higher antibody titres compared to unvaccinated calves (p = 0.002).
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