Key result
Elevated 8-ISO-PGF2alpha and ET-1 strongly correlate with decreased eGFR and predict values under 60.
Why the study?
In hypertensive patients, the relationship between oxidative stress, endothelin-1, and renal function decline remains to be clarified.
Observational (n=726)
Effect estimate: beta -0.361
p-value: p=<0.000001
In hypertensive patients, oxidative stress (8-isoprostane) and endothelin-1 are strongly and negatively correlated with renal function and are highly predictive of eGFR <60 ml/min/1.73 m2.
No takes yet. Share an insight, caveat, or question.
Should not yet change practice in hypertension; leaves open whether these markers predict CKD progression or represent modifiable targets.
Cottone et al. (2008) conducted an observational in Hypertension (n=726). 8-ISO-PGF2alpha and ET-1 levels vs. Healthy controls was evaluated on Correlation with estimated glomerular filtration rate (eGFR) (beta -0.361, p=<0.000001). Elevated 8-ISO-PGF2alpha and ET-1 levels independently correlated with decreased eGFR (beta=-0.361, P<0.000001 and beta=-0.197, P<0.0001) and strongly predicted eGFR <60 ml/min/1.73 m2.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: