Key result
Continuous ASA therapy shows no association with thrombus formation or pain complications during oral surgery.
Why the study?
The impact of acetylsalicylic acid therapy on local hemostatic thrombus formation and complications after oral surgery in patients with heart disease was unclear.
Does acetylsalicylic acid (ASA) therapy without discontinuation increase bleeding or pain complications in patients with heart disease undergoing oral surgery?
Observational (n=90)
Does acetylsalicylic acid (ASA) therapy without discontinuation increase bleeding or pain complications in patients with heart disease undergoing oral surgery?
Continuing acetylsalicylic acid therapy during oral surgery in patients with heart disease does not adversely affect hemostasis or pain, suggesting discontinuation is unnecessary.
May support uninterrupted ASA in cardiac patients for oral surgery; hypothesis-generating and requires randomized confirmation.
The acetylsalicylic acid (ASA) treatment is widespread therapeutic strategy in cardiology clinics. On the other hand, patients with heart diseases represent a significant group of cases in dental clinics. Accordingly, we studied the local hemostatic thrombus formation after dental tooth extractions (n=47) and other oral surgery treatment (n=13) in 60 patients with heart disease being on ASA therapy without drug discontinuation. In the control group free of ASA therapy it was: (n=24) and (n=6), respectively. In all studied patients, the aggregative activity of blood platelets by PFA-100 analyzer was assessed. It was found that 61.7% patients treated with ASA presented inhibition of platelets aggregation. Unexpectedly, in 35% of such patients, platelet aggregation function remained unchanged. In the control group, normal platelet aggregation was found in all subjects. It has been shown that ASA therapy has neutral effects on both thrombus formation and pain complications in patients with heart disease underwent tooth extraction and other oral surgery. Thus discontinuation of ASA therapy before surgery seems to be weakly validated.
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Dudek et al. (2013) conducted an observational in Heart disease requiring oral surgery (n=90). Acetylsalicylic acid (ASA) therapy vs. No ASA therapy was evaluated on Local hemostatic thrombus formation and pain complications. Continuous acetylsalicylic acid therapy had neutral effects on thrombus formation and pain complications in patients with heart disease undergoing oral surgery.
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