Key result
Higher LDL-C and leptin levels independently correlate with increased aortic 18F-FDG uptake.
Why the study?
The relationship between aortic 18F-FDG uptake and clinical and laboratory findings related to atherosclerosis in a general population was investigated.
Cross-Sectional (n=211)
No
Effect estimate: β = 0.336 (95% CI 0.112-0.560)
p-value: p=<0.01
Aortic 18F-FDG uptake on PET/CT correlates independently with LDL-C and leptin levels, suggesting its utility as an imaging biomarker for atherosclerosis in the general population.
May support aortic FDG uptake as atherosclerosis biomarker; cross-sectional data leave open prognostic value and clinical adoption.
OBJECTIVE: This study investigated the relationship between aortic 18F-fluoro-2-deoxy-D-glucose (18F-FDG) uptake and clinical and laboratory findings related to atherosclerosis in a general population. METHODS: 18F-FDG uptake in the ascending aorta was measured on the positron emission tomography/computed tomography (PET/CT) scans of 211 Japanese adults. The maximum target-to-background ratio (TBR) was compared with clinical and laboratory atherosclerosis findings. RESULTS: By multivariate regression analysis adjusted for age and sex, TBR-ascending aorta (TBR-A) was significantly correlated with various clinical and laboratory parameters, such as body mass index, log visceral fat area, low-density lipoprotein cholesterol (LDL-C), log fasting immunoreactive insulin, log homeostasis model assessment of insulin resistance, log total adiponectin and log-leptin, in all subjects. Furthermore, by multivariate linear regression analysis adjusted for confounding factors, TBR-A was significantly correlated with LDL-C (β = 0.001, p = 0.03) and log-leptin (β = 0.336, p<0.01) in all subjects. CONCLUSION: TBR-A was significantly correlated with LDL-C and log-leptin independent from confounding factors. Our results suggest that aortic 18F-FDG uptake is a good marker of atherosclerosis, even in a general population.
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Haraguchi et al. (2014) conducted a cross-sectional in Atherosclerosis (n=211). LDL-C and leptin levels was evaluated on Correlation of maximum target-to-background ratio in the ascending aorta (TBR-A) with clinical and laboratory parameters (β = 0.336, 95% CI 0.112-0.560, p=<0.01). Aortic 18F-FDG uptake was significantly correlated with LDL-C (β = 0.001, p = 0.03) and log-leptin (β = 0.336, p < 0.01) independent of confounding factors in a general population.
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